Synthesis and Characterization of Cyano Pyrazole

Scorpionate ligands, also known as polypyrazolylboratesare some of the most popular multidentate ligands. They are used in an extensive range of chemistry from organic synthesis to memicking metallic enzymes. Pyrazoles also have biological activities such as anti-viral, anti-inflammatory, antibacterial and antifungal. In this research, substituted cyano-pyrazoles will be synthesized and crystallized to forms of 4-cyano-3-phenyl-5-(tert-butyl) pyrazole. The product was synthesized through two different routes, one with benzoylacetonitrile and trimethylacetyl chloride and the other with trimethylacetyl acetonitrile and benzoyl chloride. We report here the synthesis results, including the solubility, reactivity, and stability of the product. The future goal is to analyze the chemical shifts and peaks using IR and 1H NMR spectrometers to compare two synthetic routes.